牛科物种甲状腺激素应答(THRSP)基因在乳脂合成中的功能作用研究进展

Research progress on the functional role of thyroid hormone response (THRSP) genes in milk fat synthesis in Bovidae

中文关键词: THRSP基因  乳脂合成  调控机制  信号通路  基因多态性

英文关键词: THRSP gene  milk fat synthesis  regulatory mechanism  expression and function  polymorphism

中文摘要:

      甲状腺激素应答(Thyriod hormone responsive, THRSP)基因参与动物从头脂肪酸的合成,主要在肝脏、乳腺和脂肪组织中表达,在转录水平上受到与脂代谢相关因子的诱导并作为转录激活剂调节下游脂肪合成酶基因的表达。本文对牛科物种THRSP基因的结构和功能、转录调控机制和调节脂肪酸合成的生物学路径及该基因多态性对泌乳性状的影响等方面的研究进展进行了综述。

英文摘要:

      Thyriod hormone responsive (THRSP) genes are involved in animal de novo fatty acid synthesis, mainly expressed in liver, mammary gland and adipose tissue, induced by factors related to lipid metabolism at the transcriptional level, and act as transcriptional activators to regulate downstream fat synthesis Expression of enzyme genes. This paper reviews the research progress on the structure and function of the THRSP gene, the mechanism of transcriptional regulation, the biological pathway for regulating fatty acid synthesis, and the effects of polymorphisms of the gene on lactation traits in bovid species.