To investigate the clinical effect of metronidazole combined with clindamycin in the treatment of cow bacterial vaginitis. Methods: 25 cattle with bacterial vaginitis were divided into three groups. Group I was the observation group, 11 cows were treated with metronidazole and clindamycin; Group II was control group 1, with 6 sick cows treated with metronidazole; Group III was control group 2, with 8 sick cows treated with clindamycin. Metronidazole Injection, 5 ~6G / head, 24h / time, continuous use for 5D, intravenous drip; Clindamycin, 1.5~2G / head, 24 h / time, continuous use for 5 days, intravenous drip. After one course of treatment, the cured cows were observed for estrus and artificially inseminated. Results: ① the clinical effective rate of the observation group was 90.91%, which was significantly higher than that of the control group 1 (80.33%) and the control group 2 (75%) (P < 0.05); ② The average treatment effect of the observation group was 72.25%, which was significantly higher than that of the control group 1 (64.92%) and the control group 2 (57.89%) (P < 0.05). ③ the oestrus rates of the observation group, the control group 1, the control group 2 and the healthy control group were 81.82%, 83.33%, 75% and 87.5% respectively. The observation group, the control group 1 and the healthy control group were significantly better than the control group 2, and there was no significant difference between the observation group, the control group 1 and the healthy control group; The conception rates of mating were 72.72%, 66.67%, 62.5% and 75% respectively. The observation group and healthy control group were significantly better than control group 1 and control group 2 (P < 0.05); The live calving rates were 100%, 75%, 80% and 100% respectively. The observation group and healthy control group were significantly better than control group 1 and control group 2 (P < 0.05). Conclusion: metronidazole combined with clindamycin is effective and safe in the treatment of bovine bacterial vaginitis, which does not affect the reproductive performance of sows, and has the value of clinical promotion; Metronidazole and clindamycin followed. |