固醇调节元件结合蛋白(SREBPs)调控牛科物种脂合成的研究进展*

Research Progress of Sterol Regulatory Element Binding Protein (SREBPs) on Lipid Synthesis in Bovidae

中文关键词: 固醇调节元件结合蛋白  牛科物种  脂合成  调控

英文关键词: Sterol regulatory element binding protein  species of Bovidae  lipid synthesis  regulation

中文摘要:

      固醇调节元件结合蛋白(Sterol Regulatory Elemental Binding Protein ,SREBPs)是细胞核内调控脂代谢的重要转录因子,其在细胞核内通过结合下游靶基因调控区的顺式作用元件来参与转录过程,进而调控脂代谢,包括调控体脂的沉积和乳脂的合成。本文综述了SREBPs的结构与功能、SREBPs参与的生物学路径及SREBP1参与牛科物种体脂沉积和乳脂合成的研究进展,旨在为牛SREBPs的深入研究提供参考。

英文摘要:

      Sterol regulatory elemental binding proteins (SREBPs) are important transcription factors that regulate lipid metabolism in the nucleus. They regulate lipid metabolism by binding cis-acting elements in the regulatory region of downstream target genes in the nucleus to regulate lipid metabolism, including body fat deposition and milk fat synthesis. This paper reviews the structure and function of SREBPs, the biological pathways involved in SREBPs, and the research progress of SREBP1 involved in body fat deposition and milk fat synthesis in the species of Bovidae, aiming to provide a reference for the in-depth study of Bovidae SREBPs.