POLB基因在动物上的研究进展

Research progress of POLB gene in animals

中文关键词: POLB基因  周期调控  细胞增殖  碱基切除修复  分子辅助标记

英文关键词: POLB gene  Cycle regulation  Cell proliferation  Base excision and repair  Molecular helper marker

中文摘要:

      DNA聚合酶β(DNA polymerase beta,POLB) 属于DNA聚合酶X家族中的一员,主要参与真核生物DNA的复制、DNA损伤修复、基因重组以及细胞周期调控等多种生物代谢过程。POLB所在的DNA修复基因与癌基因、抑癌基因、细胞周期调节基因以及细胞凋亡基因共同维持着细胞基因组的稳定性和完整性。若特异性敲除POLB会导致胚胎致死。近年来研究发现,POLB与细胞的生长发育、周期调控等息息相关。POLB表达下降使得上述的癌基因、抑癌基因受到损伤后却不能得到正确修复,从而导致细胞周期的紊乱、增殖失控。因此,本文将从POLB的基因结构、生物学功能、POLB在动物方面的研究等几个方面的相关研究进展进行综述,重点阐述其生物学功能,以期更深入了解 POLB,为畜禽品种的改良奠定理论基础。

英文摘要:

      DNA polymerase beta (POLB), a member of the DNA polymerase X family, is mainly involved in eukaryotic DNA replication, DNA damage repair, gene recombination, cell cycle regulation and other biological metabolic processes. The DNA repair gene in which POLB is located maintains the stability and integrity of the cell genome together with oncogenes, tumor suppressor genes, cell cycle regulation genes and apoptosis genes. Specific knockout of POLB can cause embryonic death. Recent studies have shown that POLB is closely related to cell growth, development and cycle regulation. The decreased expression of POLB makes the above oncogenes and tumor suppressor genes damaged but cannot be repaired correctly, leading to the disorder of cell cycle and uncontrolled proliferation. Therefore, this paper will review POLB"s genetic structure, biological function, POLB in animal research and other aspects of the relevant research progress, focus on its biological function, in order to better understand POLB, to lay a theoretical foundation for the improvement of livestock and poultry breeds.