α抗胰蛋白酶研究进展

Research Progress of Alpha Antitrypsin

中文关键词: α抗胰蛋白酶  AATD  理化性质

英文关键词: alpha antitrypsin  AATD  Physiological and biochemical properties

中文摘要:

      缺乏α抗胰蛋白酶可以引起肝炎、慢性肺阻塞等疾病。α抗胰蛋白酶的主要有抑制如凝血酶、纤溶酶、中性粒细胞弹性蛋白酶等多种丝氨酸的内切肽酶；抑制多形核白细胞（PMN细胞）的激活；清除细胞毒性物质，保护组织细胞并帮助其再生和修复的功能。本文就α抗胰蛋白酶理化性质、缺乏症极其抗病毒的治疗作用进行综述。

英文摘要:

      Alpha Antitrypsin (AAT)deficiency can cause hepatitis, chronic pulmonary obstruction and other diseases. The main function of AAT is to inhibit a variety of serine endopeptidases, such as thrombin, plasmin, neutrophil elastase, etc.; inhibit the activation of polymorphonuclear leukocytes (PMN cells); remove cytotoxic substances , Protect tissue cells and help its regeneration and repair. This article reviews its physicochemical properties, deficiency and antiviral therapeutic effects.