家畜DGAT1基因的生物学功能及其在遗传育种中的应用研究

Biological Function of DGAT1 Gene and Its Application in Genetic Breeding in Livestock

中文关键词: 家畜, DGAT1, 生物学功能, 基因多态性, 遗传育种

英文关键词: Livestock, DGAT1, Biological  function, Genetic  polymorphism, genetic  breeding

中文摘要:

      DGAT1基因属于酰基辅酶A胆固醇酰基转移酶(acyl CoA:cholesterol acyltransferase，ACAT)基因家族，DGAT1基因催化反应的底物为二酰甘油和乙酰辅酶A(fatty acyl CoAs)，该基因一方面参与脂肪的合成，在细胞中起到重要的中心代谢作用，另一方面作为影响家畜泌乳性状和脂肪沉积的重要候选基因，被认为对乳脂合成、脂肪含量和食用价值均有显著影响。本文通过对DGAT1基因的生物学功能、分子结构以及该基因多态性与各类家畜经济性状的关联性进行综述，阐明该基因在家畜发育中的遗传表达规律，并对DGAT1基因在家畜育种方面的研究前景做出展望。

英文摘要:

      DGAT1 gene belongs to the acyl coenzyme A cholesterol acyltransferase (acyl CoA: cholesterol acyltransferase, ACAT) gene family, DGAT1 gene catalytic reaction of the substrate for the acyl glycerol and acetyl coenzyme A (fatty acyl CoAs), the genes involved in the synthesis of fat on the one hand, metabolism in the center of the cells play an important role, on the other hand, as the influence of properties of milk secretion and important candidate genes of fat deposition, is considered to the milk fat synthesis, fat and edible value have significant impact. In this paper, the biological function and molecular structure of DGAT1 gene, as well as the relationship between the polymorphism of DGAT1 gene and various economic traits of livestock were reviewed, the genetic expression of DGAT1 gene in the development of livestock was clarified, and the research prospect of DGAT1 gene in livestock breeding was prospected.