脊椎动物神经嵴细胞发育相关非编码RNA研究进展

Research progress on non-coding RNAs related to neural crest cell development in vertebrate

中文关键词: 神经嵴细胞，发育，非编码RNA

英文关键词: Neural crest cell  Development  non-coding RNA

中文摘要:

      神经嵴是脊椎动物胚胎发育中的一种过渡性结构,神经嵴细胞经诱导后可迁移、分化成机体多种类型的细胞以形成重要组织的一部分。研究显示,部分非编码RNA对神经嵴细胞发育具有一定调控作用。非编码RNA是一种不参与编码蛋白质,对转录后水平的基因表达有调控作用的RNA。神经嵴细胞的正常发育影响着机体重要组织的发育,相关研究对于色素异常、肠道神经节细胞发育异常等遗传性疾病的治疗具有重要意义。本文综述了近几年与神经嵴细胞发育相关的非编码RNA研究进展。

英文摘要:

      Neural crest is a kind of transitional structure in embryonic development of vertebrate. Neural crest cells may migrate and differentiate into various types of cells after induction to form various important tissues and organs. Studies have shown that some non-coding RNAs have a certain regulatory effect on the development of neural crest cells. Non-coding RNA is a kind of RNA that does not participate in the encoding of proteins and regulates the expression of genes at the post-transcriptional level. The normal development of neural crest cells affects the form of important tissues of the body, and related research is of great significance for the treatment of genetic diseases such as abnormal development of pigment and intestinal ganglion cells. This article reviewed the progress of non-coding RNA studies related to neural crest cell development in recent years.