RNA m6A甲基化修饰的研究进展

Recent Progresses in RNA m6A Methylation Research

中文关键词: m⁶A甲基化  甲基转移酶  去甲基酶  识别蛋白  调控功能

英文关键词: N⁶-methyladenosine (m⁶A)  methyltransferase  demethylase  reader proteins  regulatory function

中文摘要:

      RNA m⁶A甲基化修饰是发生在RNA腺嘌呤（A）第6位N原子上的一种转录后修饰方式。它是由甲基转移酶和去甲基酶以及识别蛋白所催化的一种动态可逆的修饰方式，具有重要的调控功能。本文综述了m⁶A甲基化的发现、相关酶的作用以及在生命过程中的重要功能，以期对未来研究m⁶A在牛的遗传育种方面的调控作用提供重要的理论支持。

英文摘要:

      RNA m⁶A methylation is a post-transcriptional modification that occurs at the sixth N atom of RNA adenine. m⁶A is a dynamically reversible modification that catalyzed by methyltransferase, demethylase and reader proteins. It has important regulatory functions. In this review, we summarized the discovery of m⁶A, the role of related enzymes, and vital functions in biological significance, which will provide important theoretical support for the research on the regulation of m⁶A in the genetics and breeding of cattle.